Since breast cancer cells exhibit tropisms for specific tissues [4], [26], [35], we evaluated whether BAPN treatment might alter tissue-specific pattern of metastasis.
Since prodrugs might alter the tissue distribution, efficacy and the toxicity of the parent drug, prodrug design should be considered at the early stages of preclinical development.
15 Another possible mechanism explaining the link between RBP4 and NAFLD is that changes in retinoid metabolism induced by RBP4 might alter the tissue level of retinol.
Elevated CO2 and drought alter tissue water relations of birch (Betula populifolia Marsh). seedlings.
Early-life exposure might alter development of adipose tissue in terms of number, size, and distribution of adipocytes formed, or it may affect the larger regulatory systems involved in weight homeostasis (Grun and Blumberg 2009).
Reduced decorin levels in cancer tissues might alter several signal pathways due to the well known interactions between decorin and the tyrosine kinase receptors described above.
Thus, isoflavones might alter free thyroid hormone concentrations, resulting in altered tissue availability, metabolism, renal excretion (Schröder-van der Elst et al. 2003), and, as a consequence, disturbed feedback to the pituitary.
Even herbivores with specialized diets might alter their intake of plant tissue types of varying defensive value in response to parasitism or disease.
Exclusion criteria: Subjects with other pathology features or infection of the ocular surface that might alter wound healing, mainly connective tissue disease and diabetes were excluded.
Some research studies shows that, while placing mobile phone nearer to head, the emitted EM radiation gets coupled to human head tissues, which might alter the basic biological function of cells.
