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Therefore, we carried out experiments to ascertain if GSK3 might also repress HSF1 independently of S303 phosphorylation in mammalian cells.
We are currently investigating whether R2R3-MYB candidates in grapevine might also repress the transcription of the VvCHS genes during the induction of the stilbene biosynthesis pathway.
The effects of CAL-101 in inhibiting Akt activation and cell proliferation in AML cells led us to hypothesize that CAL-101 might also repress rRNA synthesis.
Since Ssu72 represses a specific class of ncRNAs the SRTs we asked whether H2A.Z or H3-K56Ac might also repress some ncRNAs.
As recently demonstrated on a medulloblastoma model, this drug might also repress these two signalling cascades through the induction of PTEN expression [ 28].
RhoGEF2 and DRac1 also upregulate JNK signalling (Brumby et al., 2011; Khoo et al., 2013), and might also repress Hippo signalling to promote tissue growth, since regulators of actin cytoskeletal tension, such as activated Rok and Myosin II regulatory light chain, induce Yki target gene expression (Fernandez et al., 2011; Halder et al., 2012; Rauskolb et al., 2014; Sansores-Garcia et al., 2011).
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In TR/GR-null livers, Nrf2 activity is further induced, revealing that TrxR-independent systems also repress Nrf2 and these might be induced by more extreme challenges.
This would suggest that TGFβ1 might also be repressing translation/export of proteins or could be modulating expression of tissue-specific microRNAs (miRNAs), short nucleotide sequences involved in post-transcriptional gene regulation that have been implicated in endometrial function [29], [30].
Another potential target gene is the anti-apoptotic molecule Bcl XL, which was found to be upregulated in plakoglobin-deficient cells leading to reduced apoptosis and thus might also be repressed by plakoglobin (Dusek et al. 2007a).
In addition, Puf proteins can also repress translation independently of deadenylation and therefore might also promote deadenylation indirectly (Chritton and Wickens 2011).
The two riboregulators can also repress each other by antisense interaction, although not symmetrically.
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