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Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes.
In Drosophila, NCenH3CID contains two other conserved motives that might also mediate interactions with kinetochore components.
The second hypothesis would be that CDK11p58 might also mediate its role via its direct interaction with Plk4.
It indicated that mTOR might also mediate the phosphorylation of STAT3 at Tyr705, not only at Ser727.
Therefore, we reasoned that IFN-γ and/or TNFα might also mediate the intrinsic apoptosis pathway to sensitize colon carcinoma cells to TRAIL-induced apoptosis.
On the other hand, PGE2 was recently shown to stimulate self-renewal of hematopoietic stem cells [47], so we reasoned that it might also mediate similar effects on hESCs.
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The regenerative effect of stem cells and their progenies might be also mediated by a reduction of inflammation at the wound site.
This observation raises the possibility that the renewal and differentiation of branchial ionocytes in adult gills might be also mediated by a foxi3-dependent pathway.
Notch could also regulate osteoclastogenesis, through the up-regulation of RANKL and OPG genes, suggesting that the functional cross-talk between osteoblasts and osteoclasts might be also mediated by Notch signaling.
The increased neutralization capacity might also be mediated by a PRO 2000-induced secretion of antiviral mediators or immunoglobulins, however a recent clinical study has shown that PRO 2000 dampened immune mediator secretion rather than inducing it [17].
This observation suggests that epidermal IC cell fate choice might also be mediated by the Delta-Notch lateral inhibition mechanism.
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