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We next examined whether Jas might also attenuate the dissociation of cofilin from the actin network.
Finally, active smoking in most studies was self-reported, which might also attenuate the possible association between active smoking and breast cancer risk.
Adjuvant chemotherapy, in addition to its direct cytotoxic effect on cancer cells, might also attenuate surgery-stimulated tumour cell proliferation and angiogenic surge possibly occurring at distant dormant or indolent micrometastases (Retsky et al, 2004).
Hence, we expected that TNFR2 deficiency might also attenuate O3-induced AHR in obese mice and might even ablate obesity-related differences in the impact of O3 on AHR.
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RhoA activation is associated with entry and exocytosis of viruses, and LPA might synergize with these events and also attenuate the antiviral efficacy of macrolide antibiotics.
These deficiencies, working individually or in combination, might also have attenuated between-group differences.
As a result, localized plasminogen activation at the fibrin clot might also be attenuated.
HIF-1 activity might also be attenuated by previously used chemotherapeutics such as anthracycline and doxorubicin, which act by inhibiting HIF-1 α DNA-binding activity, and acriflavine, which prevents HIF subunit dimerisation [ 130, 131].
The lack of activation/overexpression of EGFR family members and the lack of activation of Src in the bitransgenic tumours suggested that signalling mediated by secondary signalling molecules might also be attenuated in the bitransgenic tumours when compared with c-ErbB2 tumours.
Heat shock pretreatment could also attenuate the electrocortical dysfunction in rats with LPS-induced septic response, suggesting that HS induced Hsp72 might potentially be used to prevent septic encephalopathy in sepsis [ 24].
SF can also attenuate the TNF/TNFR-induced inflammation of OA chondrocytes and downregulate the NO synthesis and PGE2 release, which might be due to suppression of the IKK/NF-κB signaling pathway.
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