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Further analyses are necessary to clearly elucidate the mechanisms by which the gene might affect disease progression.
How changes in pulsatile pressure and flow in the brain might affect disease development and progression is a question of recent interest.
It is important to emphasize that the ages and levels in our simulations should be interpreted in a relative sense to gain an understanding of how pathway dynamics might affect disease characteristics.
In addition, E. granulosus distribution, host susceptibility, and strain variation might affect disease transmission in different areas of the Peruvian Highlands (to our knowledge, no studies have tried to characterize E. granulosus strains in Peru).
As the enzyme aromatase is more abundant in overweight women, it has been hypothesised that standard dosages of aromatase inhibitors are not able to equally suppress estrogen serum levels in overweight and normal weight patients, which might affect disease outcome.
Our data also indicate that certain genetic changes might affect disease severity or human-to-human transmissibility, suggesting an active period of adaptation that could result in virus strains with increased fitness in humans.
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Land use-driven biodiversity change might predictably affect disease risk if reservoir host species are consistently more likely to persist under human disturbance (ie, if ecological communities in modified habitats generally have a higher zoonotic potential than those in unmodified habitats).
In the worst case, modifying the biomarker level through diet change might not affect disease.
These genes might also affect disease resistance upon Cylindrocarpon destructans infection.
Therefore, the difference in the age of patients might affect the disease severity.
Resistance genes identified by linkage or association mapping might affect the disease either directly or indirectly (cf.[ 18, 19]).
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