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A drug might affect cells that are normal as well as cells that need to be fixed, causing side effects.
The exact biologic effects of synovial IL-20 have yet to be determined, but it is tempting to speculate that this cytokine might affect cells present in inflamed synovium.
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Detachment of cells using trypsin is not recommended as it might affect cell surface proteins which this method aims to isolate.
These five proteins might affect cell polarity through intracellular trafficking.
Since FLJ10540 is overexpressed in lung adenocarcinoma and a highly invasive lung cancer cell line, it seemed possible that its expression might affect cell motility.
Although the capacity of GSH to abrogate the activity of NSMase is well established, GSH could have other effects on bacterial sonicates that might affect cell apoptosis.
The reduction of maximum stress of the F-actin-FLNa network by these two mutations, therefore, might affect cell survival under large mechanical stress.
These findings suggest that Pkd1 or/and Kif3a deficiency might affect cell fate decision between osteoblastogenesis and adipogenesis through regulation of hedgehog signaling pathway.
Other factors like the protein to be overexpressed or depleted might affect cell growth and viability and result in lower viral titers than expected.
Because our BrdU incorporation data suggested that Barx2 could induce re-entry of myotube-derived cells into the cell cycle, we examined whether Barx2 might affect cell cycle genes directly.
The decrease in proliferation and in Runx2 expression in the perichondrium also suggests that c-Myc regulates expansion of osteoblasts, but the less-well defined architecture of the perichondrium compared to the growth plate is not amenable to an accurate determination of how loss of c-Myc might affect cell density at this location.
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CEO of Professional Science Editing for Scientists @ prosciediting.com