Exact(4)
Experiments on aging tend to take a long time even in mice, which live for two years, so Dr. Guarente chose to look first in yeast for genes that might affect aging.
Aging had long been a difficult and unpromising field for biologists, but Dr. Guarente said his students could have a year to search for genes that might affect aging in yeast.
Stem cell biologist Amy Wagers and cardiologist Richard Lee, both of the Harvard Stem Cell Institute, wondered if any circulating factors, in young blood, such as hormones, might affect aging hearts.
To test our hypothesis that inhibitory CD33rSiglecs might affect aging by regulating ROS homeostasis, we used mice as a simplified model system as deletion of Siglec-E results essentially in the removal of most of the CD33rSiglec receptors from macrophages and neutrophils, which are the main producers of ROS upon inflammatory stimuli.
Similar(56)
A recent study indicated that N370S might affect age of onset and may also contribute to LOPD susceptibility in Chinese Han populations [ 8].
34 This suggests that peoples' attitudes toward aging might affect their own aging process in a sort of self-fulfilling prophecy.
The resistance against HFD-induced obesity suggests that the transgenic expression of hNAG-1 in mice might positively affect age-associated metabolic disorders, such as insulin resistance.
To this end, our studies focus on clinical and translational research efforts ranging from: (1) the analysis of gene changes which predispose individuals to exceptionally youthful skin to (2) molecular signatures that may be biomarkers for aging skin to (3) the careful study of new candidate agents which might affect the skin aging process.
In addition, it is questioned whether exercise during second and third trimesters of pregnancy might affect gestational age and increase the risk of preterm delivery.
We investigated factors that might affect menarcheal age in 81 606 women participating in the Breakthrough Generations Study (BGS), to improve understanding of the causation of menarche both as a significant biological event and as a breast cancer risk factor.
Their average lifetime is about 3 years, and recent studies have shown that zebrafish exhibit aging-related degeneration, suggesting the possibility that aging might affect regenerative potential.
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