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The shift size parameter should be set as the midpoint of the average sonication fragment length in the analyzed dataset.
The mean length of follow-up in this study was 5.9 years and assuming that current users of EPT remained users during follow-up, this changes the values to be used in estimating OR1 from 2.5 and 7.5 years to 5.45 (2.5 plus the midpoint of the average follow-up, i.e. 5.9/2 or the average exposure during follow-up) and 10.45 (7.5 + 5.9/2) years, respectively.
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To quantify this effect, we measured the melting force at the approximate midpoint of the transition (averaging the observed force over the extension range of 0.44−0.46 nm per base pair).
Images were acquired and analyzed using Volocity software (PerkinElmer, Waltham, MA, USA) with Z-stack images taken at 0.354 μm increments across 10 μm sections to the either side of the midpoint of the oocyte, and average mean fluorescent intensity obtained from each sample was used for comparative purposes and expressed as random fluorescent units (RFUs).
These forces are determined by finding the force at the midpoint of the melting transition, averaging over the extensions of 0.44−0.46 nm per base pair to minimize any variations due to subtle changes in the slope of the transition.
Pfizer forecast 2013 earnings of $2.20 to $2.30 a share, excluding special items, with a midpoint below the average analyst estimate of $2.29 a share, according to Thomson Reuters.
The threshold was set as the midpoint between the average fluorescence amplitude of positives and negative droplet clusters on each of the FAM and VIC channels.
To compute significance of modulation, the SPW-R-aligned raster of each unit was bootstrapped to derive and compare confidence intervals, at the p<0.05 level, of a 50 ms bin at the midpoint of the SPW-R event and the average of the confidence intervals of the 300 ms baseline.
Note that all of the mean scores had values less than the midpoint of the scale (3), indicating, on average, agreement with all the changes.
The average distance from the midpoint of the posterior border of the basal turn of the cochlea to the facial nerve was 11 ± 1 mm.
Auvinen et al (2002) estimated mean lead time and then inferred the MST, assuming that cancers in the first round of screening are detected on average in the midpoint of the MST.
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