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Its persistence in humans represents an abnormality that occurs in a wide range of disorders of the midline, such as holoprosencephaly [ 1].
Various other white spotting phenotypes show spotting at the ventral midline, such as lockets and belly spots, or white at the extremities, such as gloves and mittens.
In addition, patients may present with several other defects of the ventral midline such as cleft lip and palate and congenital heart defects.
Sequencing of pediatric HGG tumors identified a recurring somatic mutation of H3 lysine 27 to methionine (K27M) in ∼30 % pediatric HGG tumors (Wu et al. 2012; Schwartzentruber et al. 2012), mainly in tumors of the midline such as the thalamus, basal ganglia, and spinal cord (Sturm et al. 2012).
We note that Hb9-GAL4 expressinitiatesatearlierier than ap-GAL4 and includes a larger number of neurons, including some located near the CNS midline (such as the RP motor neurons), suggesting the possibility that early midline-proximal expression of Robo2 accounts for the non-autonomous effect observed with Hb9-GAL4.
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A very aggressive poorly differentiated carcinoma that originates mainly from midline locations such as the head, neck or mediastinum is NUT (nuclear protein in testis) midline carcinoma (NMC) (Ref. 132).
Likewise, although midline shift or cisterns status is important in the Marshall Classification of brain swelling, other causes of midline shift, such as mass lesion, are disregarded.
Schizophrenia has also been associated with decreased size of several midline structures such as the hippocampus and corpus callosum, again suggesting that CSP may be related to abnormalities in midline development in this condition.
We hypothesized that schema retrieval would primarily engage neocortical midline structures, such as the MPFC.
First, the surgeries in monkeys were more extensive, including thalamic midline nuclei such as nucleus reuniens.
In particular in combined (medullocerebellar) midline pathologies, such as in transforaminal cerebellar herniation [ 29], it is essential to study the micromorphology of these areas in detail.
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