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Exact(4)
From a galore of fascinating experiments we learned that the same result (to cross or not to cross the midline) could be achieved using a number of different genes through different regulatory mechanisms depending upon the neurons and the context (ephrins, plexins, robos).
There are arguments to think that a small amount of Robo on the growth cone is not just an accident: sudden activation of that little Robo present on the growing tip of the axon immediately after reaching the midline could be an efficient way for the neuron to overcome stalling and provide a quick switch from attraction to repulsion.
The benefit of the incision point being away from the midline could be a consequence of directing pressure away from the midline already at the incision point.
Exposure to ramoplanin caused septal deformations, and loss of the septal midline could be due to ramoplanin-induced cell wall biosynthesis inhibition (5, 6) or/and membrane depolarization that could affect autolysin activity, which is important in the regulation of autolysis (40, 72).
Similar(56)
Diastemas, tipping, retention of deciduous teeth, and midline deviation could be common in these patients if not treated.
Finally, we performed a comparative study of species that retain an open canal in order to describe the distribution of BHC persistence amongst vertebrates and we have attempted to relate the presence or absence of the BHC with modifications in midline anatomy that could be due to modulation in Shh signaling.
Confidence in the MO data is especially important given that the main phenotype that is shown for many of the experiments (a failure of angioblasts to migrate to the midline) could also be explained by a generalised developmental delay.
Using this method, the accurate distance from pelvic midline to the FHC could be obtained and a newly developed graduated ruler was used to replicate this distance.
For example, when the category of the ILD function for the onset response component was Contra-selective, the category of the late response component could be Midline-selective, Complex or ILD-insensitive.
The target location within the image was selected at random but was at least 0.55° from the vertical midline so that the side could be readily judged.
Another possible cause of omphalocele could be a midline defect at the amnio-ectodermal transition, the transition zone between the ectoderm and mesoderm, which would result in an enlarged umbilical ring [2], [7], [11], [12].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com