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The middle subnetwork was densely connected.
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Figure 4 shows that miRNAs in the middle subnetwork were densely connected.
Genes in the middle of the subnetwork are highly connected: these 121 genes (25% of total genes) have 2,088 connections (85% of total connections) in the T2D network.
One subnetwork was retrieved for each transition between consecutive HCC stages, and the four subnetworks are termed "transition-wise" subnetworks hereafter.
The MKL subnetwork was highly enriched with these processes, outperforming the ANAT and the Steiner subnetworks (Table 2).
This subnetwork is called the core.
Generally, the more homogeneous the lower subnetwork is, the better the transmission performance, which is the opposite for the upper subnetwork.
The individual networks comprising an internetwork are called subnetworks, the devices connected to a subnetwork are called end nodes, and the devices that interconnect subnetworks are called intermediate nodes.
The cancer subnetwork is shown in Figure S3.
Note that a highly interconnected subnetwork does not mean that the genes in the subnetwork are significantly differentially expressed.
This subnetwork is called SuN.
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