As compared with those in low (L-Hcy) and middle (M-Hcy) plasma level of Hcy groups, patients in H-Hcy group had higher diastolic blood pressure (DBP) and higher ratio of male (P<0.05), while there was no difference between other characteristics including age, heart rate, BMI, systolic blood pressure (SBP), EF, and Gensini score (P>0.05).
Determining the plasma level of middle molecules can be used as an additional dynamic criterion of severity of endogenous intoxication in community-acquired pneumonia.
In recent years there is a revival of interest to the plasma level of middle molecules which is the marker of activation of endogenous proteolysis and the expressiveness of endogenous intoxication syndrome.
In the middle aged/elderly subjects, the mean plasma level of KL-6 was higher in both smokers and subjects with COPD when compared to non-smokers (non-smoker 309 ± 35 U/ml, smoker 478 ± 31 U/ml, COPD 589 ± 61 U/ml; p = 0.003 and p < 0.001, respectively).
In addition, in middle aged/elderly subjects, plasma levels of KL-6 in all smokers were higher than in non-smokers.
Mean plasma level of KL-6 was higher in the middle aged/elderly males with COPD when compared to non-smokers in the group (middle aged/elderly male non-smokers 292 ± 78 U/ml, middle aged/elderly males with COPD 556 ± 64 U/ml; p = 0.037).
Diastolic blood pressure, ratios of male, renal failure and old myocardial infarction in high plasma level Hcy (H-Hcy) group were higher than those in low (L-Hcy) and middle (M-Hcy) plasma level of Hcy groups (P<0.05).
Finally, plasma level of corticosterone was determined.
NP interpreted ganciclovir plasma level.
Over 15 years ago, an association between enhanced inflammations, as demonstrated by higher plasma levels of CRP in middle-aged men without previous cardiovascular disease, was reported using data from the Multiple Risk Factor Intervention Trial (MRFIT) [ 100].
