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READING I'm in the middle of reading a book called "The Women Were Leaving the Men".
You're in the middle of reading a long, important document, but suddenly find you can't concentrate.
Age notwithstanding, she is in the middle of reading them now.
"I was in the middle of reading the book on my Kindle," said another.
"Right now, I've literally got 8 or 10 books about elephants I'm in the middle of reading.
An actor, gazing lovingly at a Grecian urn, was in the middle of reading Ode on a Grecian Urn.
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There seem to persist chemical or mechanical biases in the process that lead to surprising biases, such as overrepresentation of some k-mers in the middle of reads.
Bases at the ends of reads can have a substantially higher error rate than bases at the beginning and middle of reads.
The underlying assumption is that the average frequency with which a hexamer appears in the middle of reads is not affected by library preparation biases.
The effect of this correction procedure is to reduce (respectively increase) the multiplicity of reads with starting hexamers that are overrepresented (respectively underrepresented) at the beginning of reads compared to the middle of reads.
The merging step may introduce errors into the middle of reads that will largely complicate the de Bruijn graph used in assembly and result in incorrect assembly results in S. parasanguinis FW213.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com