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It would be possible to predict how middle ear function is affected by various kinds of middle ear pathologies and to understand how individual differences in middle ear structures affect that function prior to surgery.
Clearly, such an in vivo diagnostic approach should allow direct visualization through the tympanic membrane, thereby allowing clinicians to determine transtympanic middle ear pathologies.
The chemical imaging of middle ear pathologies, however, is largely unexplored and no method exists to reproduce or exceed otoscopic capabilities.
In middle ear pathologies, the inability to avail high-resolution structural and/or molecular imaging is particularly glaring, leading to a complicated and erratic decision analysis.
Secondly, the BB does not require a good middle ear structure for the coupling of the device; thus it is suitable for patients with middle ear pathologies and who are not feasible for VSB implantation.
By combining the exquisite chemical specificity of Raman spectroscopy with wide-field fluorescence imaging, a multidimensional algorithm capable of differentiating a broader range of middle ear pathologies may be obtained.
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Biomechanics and modeling of the human middle ear are also used in the study of middle ear pathology and the development of hearing devices.
Multi-color reflectance imaging of middle ear pathology in vivo.
Multiwavelength fluorescence otoscope for video-rate chemical imaging of middle ear pathology.
Multi-color reflectance imaging of middle ear pathology in vivo.. Analytical and bioanalytical chemistry.
Multi-wavelength fluorescence otoscope for video-rate chemical imaging of middle ear pathology.
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