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During the recent Finnish Otitis Media (FinOM Cohort Studyy, in addition to nasopharyngeal aspirates (NPA) and middle ear fluids (MEF), paired acute and convalescent serum samples were collected from children with AOM.
Twenty-four hours later, chinchillas were transbullarly challenged with NTHI and the resultant middle ear effusions were collected 2 and 4 days after bacterial challenge to determine the concentration of NTHI present in these middle ear fluids.
Although purified native cSPLUNC1 killed NTHI in vitro, the concentration of NTHI in middle ear fluids after transbullar challenge was not increased by a knock down in cSPLUNC1 expression, compared to controls.
Protection from NTHI colonization by increased clearance of the bacteria and reduction in accumulation of middle ear fluids reveal the functional capacity of vaccination against molecules expressed by NTHI.
Out of 5,280 mutants tested, 248 mutants were substantially underrepresented in the mutant pools recovered from the middle ear fluids of the infected chinchillas, indicating the impaired ability to survive and replicate in the middle ears due to genetic disruptions in the chromosome of strain ST556.
Middle ear fluids were visually analyzed and categorized into serous or mucous groups.
Similar(51)
There is no predictive value of CN in terms of character of the middle ear fluid.
Conclusions: Negative pressure tympanogram is a poor indicator for the presence of middle ear fluid.
Myringotomy with aspiration was performed if middle ear fluid was suspected in otoscopy.
In May 2004, the American Academy of Pediatrics published new clinical guidelines to help physicians treat children with the lingering middle ear fluid.
Occurrence of middle ear fluid in ears with negative pressure tympanograms (less than −100 daPa) was assessed.
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