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Two were given a low dose, two a middle dose and two a high level.
Rats of low dose, middle dose and high dose group simultaneously received tamarind fruit pulp extract at three doses 25 (low), 50 (medium) and 100 mg (high) per kg body weight orally, respectively.
When GC/MS-based metabolomics was applied to humoral fluid of zebrafish (Dario rerio) exposed to three different doses of IFN-α2b, designed as IFN-L (low dose), IFN-M (middle dose) and IFN-H (high dose), forty-three IFN-responsive metabolites were identified.
The high dose, middle dose, and low dose of curcumin were 0.8, 0.4, and 0.2 ìg/ml, respectively.
Consistent with acid base status parameters, low dose, middle dose and high dose of NNAV all significantly increased PO2 and SO2 values and decreased PCO2 value.
Osteoid and rhabdoid differentiations, both known in human cases, 14– 16 were found in nine mice (two in the low dose, three in the middle dose, and four in the high dose group, respectively) among a total of 41 mesothelioma cases in the present study.
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Taking into account the AL cost in the International Drug Price Indicator (2008 version) that showed a reduction of 32.8% (lowest dose), 33.25% (for the middle doses) and to 36.9% (adult dose) [ 26], a sensitivity analysis revealed a high reduction in the cost of the presumptive-BS by 37.14%, in paracheck-BS by 14.93% and in parascreen-BS by 10.05% (Table 4).
As per OECD [ 16] guideline, after the safety evaluation of the plant, 1/10th of the maximum dose (2000 mg/kg) was considered as a middle dose, half and double of the middle dose were taken as the low and the high doses, respectively.
Nine normal rats were randomly selected as normal group, and 36 rats with CIA were divided into four groups, which are CIA group, TP-LHP low dose group, TP-LHP middle dose group, and TP-LHP high dose group.
Toxicity of honokiol was evaluated in rats by intravenous administration with low-dose, middle-dose and high-dose once a day for 14 days.
This mitochondrial damage was slightly mitigated in the LPS + low-dose NaHS group and significantly mitigated in the LPS + middle-dose and high-dose NaHS groups.
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