Sentence examples for middle base of from inspiring English sources

The triple is consequently centered about the middle base of the probe (δ = 0) or shifted by δ sequence positions up or downwards (δ≠0).

The shift of mismatch motifs by a few sequence positions about the middle base of the probe and the effect of flanking mismatches adjacent to triples with a central mismatch can be neglected to a good approximation.

As the elementary sequence motif we chose triples of subsequent nucleotides centered about the middle base of the probe and/or about the SNP base and calculate log-averages of the intensities over thousands of probes with identical motifs to average out the effect of the remaining sequence.

For example, the C. albicans tRNACAGSer contains identity elements for the LeuRS, namely m1G37 and the middle base of the anticodon (A35), but the discriminator base at position 73 (G73) is specific for SerRS and not for LeuRS (A73 discriminator) [62].

Thus, we designed KRAS2 PNA-IGF1 tetrapeptide agents with an internal TO adjacent to the middle base of the 12th codon, a frequent site of cancer-initiating mutations.

Thus, we designed KRAS2 PNA-peptides with an internal TO adjacent to the middle base of the 12th codon, a frequent site of cancer-initiating mutations, such as G12D (Table 1; Figure 2).

The different middle bases of both probes of one pair cause different base pairings in the respective probe/target-duplexes and thus different binding constants (see below and [ 16]).

The structural feature table of 3-mer is a 64 by 6 matrix, which contains six real value "base" parameters for each middle base pair of all the 64 (4) different 3-mers.

In this section we specify the base pairings formed in the probe/target duplexes at two selected sequence positions, namely that of the SNP- and that of the middle-base of the probe sequence.

The base parameters measure the relative relations between two fundamental units of the middle based pair of a 3-mer in a 3-dimensional space.

Also the homozygous-present duplexes of the MM-probes, MM-GG, form predominantly WC pairings except the middle base which forms mismatches of the Aa-interaction group.