If they then became parent-like, authoritarian and wealthy, they also left their progeny destitute upon their departure on 1947: so the middle-aged offspring might have some reason for complaint.
On one level a multigenerational family epic featuring a retired railroad employee who's losing his marbles, his frazzled wife and their unmoored middle-aged offspring, this novel, chosen by the editors of the Book Review as one of the best books of 2001, is also a densely subplotted disquisition on the minutiae of railroads, drugs, economics, cuisine, Eastern European politics and lots more.
We used a proven family design, comparing middle-aged offspring with and without a parental history of AD.
Family-based cohorts : Family-based longevity studies consist of nonagenarians/centenarians (siblings) and their middle-aged offspring.
Blood plasma GPLs and other lipids are also associated with 'familial longevity' in middle-aged offspring of human nonagenarians (Gonzalez-Covarrubias et al. 2013).
By comparing middle-aged offspring of AD cases with similar offspring of nondemented parents, the authors observed increased proinflammatory responses and increased hypertension in those at genetic risk.
In seeming contrast, earlier we reported on the lack of differences in serum levels of IGF-1 axis parameters between middle-aged offspring of familial nonagenarians and controls [ 19].
Middle-aged offspring of nonagenarians, as compared to their spouses (controls), show a favorable lipid metabolism marked by larger LDL particle size in men and lower total triglyceride levels in women.
Such an interpretation seems to be in agreement with a recent observation that middle-aged offspring of nonagenarian siblings have low circulating concentrations of FT3 with respect to their middle-aged partners [ 20].
They compared middle-aged offspring of AD cases with similar offspring of nondemented parents and observed greater inflammatory response to challenge and increased hypertension in those at high genetic risk.
