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To generate anchor-based values for the "minimally important difference" (MID) for a number of commonly used patient-reported outcome (PRO) measures and to examine whether these values could be applied across the continuum of preoperative patient severity.
There is no one best way to estimate the MID for a PRO measure [ 21, 34].
For these reasons, we cannot have a unique MID for a PRO instrument, good for different diseases and patients [ 7].
Demonstrating responsiveness is necessary, but additional information is needed to determine the minimally important difference (MID) for a PRO measure.
We will, in addition, search the citation lists of included studies and collect narrative and systematic reviews for original studies that report an MID for a given instrument.
Finally, the application of multiple methods to determine the MID for a PRO instrument in a specific patient population will result in a range of values for the MID.
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