Sentence examples for mid domain of from inspiring English sources

Further structure analysis showed that in human Ago2 one of the aromatic side chains F450 is buried in the hydrophobic core (Kinch and Grishin, 2009) and MID domain of human Ago2 cannot bind cap analogues significantly (Frank et al., 2011), although Drosophila Ago1 and Neurospora Argonaute contains a 5′ cap binding site (Boland et al., 2010; Djuranovic et al., 2010).

Furthermore, there is tertiary structural similarity between YbeY and the MID domain of Argonaute [ 29].

The highly conserved bacterial YbeY RNase has structural similarities to the MID domain of AGOs.

Similarly, the 'H' at position 2505 in the MID domain of Class I AGO is highly correlated to residue 'Q' at position 2906 in PIWI domain.

These piRNAs would be crosslinked through their 5′ phosphate, consistent with the interactions between this phosphate and the MID domain of Argonaute proteins (Schirle and MacRae, 2012).

In this study, we report the crystal structure of the MID domain of the eukaryotic AGO protein QDE-2 from Neurospora crassa.

We present a multiple sequence alignment between the corresponding mid domains of eukaryotic Ago representatives and prokaryotic piwi structures that allows confident mapping of key Ago2 residue positions.

Solanezumab is the exception; it binds the mid-domain of monomeric, but not aggregated, Aβ with extremely high affinity [ 22, 23].

Gantenerumab is also a human IgG1 antibody which recognises a conformational epitope, making contact with the n terminus and the mid-domain of Aβ, reportedly binding more strongly to more aggregated forms compared to soluble Aβ [ 3].

Solanezumab (LY2062430) is a humanized monoclonal IgG1 antibody directed against the mid-domain of the A β peptide (A β 16 24) and designed to specifically bind soluble species of A β. Phase 2 study showed dose-dependent increases of various A β species in plasma and CSF, an indication that insoluble A β is released from plagues and leaches into fluid [ 103].

Input alignments of the Ago2 mid domain with most of the identified structure templates yielded models with similar final total energies (1ytu, -3418 KJ/mol; 2bgg, -4004 KJ/mol; 1w9h, -4050 KJ/mol; 2f8s, -3922 KJ/mol; 2f8t, -4303 KJ/mol; 2nub, -3847 KJ/mol; 1yvu, -3748 KJ/mol; and 1z25, -3420).