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CMED may lead to a coronary microvascular vasospasm.
Aim: The aim was to verify the presence of a microvascular vasospasm of cerebral cortex in "prolonged" aura migraine.
Conclusions: In conclusion during "prolonged" migraine aura we find cortical areas of microvascular vasospasm corresponding to the topography of aura symptoms and suggesting the presence of a microvascular endothelial dysfunction.
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Hand disability has multifactorial origins with microvascular lesions, paroxysmal vasospasm or permanent ischaemia and subsequently digital ulcers (DU), skin sclerosis, tendons retractions, bone and articular involvement, and subcutaneous calcinosis.
7 Given that the pathophysiological events that underlie DCI are primarily vascular (vasospasm, microvascular dysfunction, and microvessel thrombosis), a conditioning-based strategy capitalizing on endogenous protective cascades that robustly protect the cerebrovasculature (as well as neurons and glia) would represent a powerful, novel intervention for SAH-induced DCI.
There are also evidences to suggest that abnormalities of endothelium-dependent vasodilatation contribute to the clinical syndromes of microvascular angina and coronary vasospasm [ 42].
Isoflurane postconditioning initiated at clinically relevant time points after SAH significantly reduced cerebral vasospasm, microvessel thrombosis, microvascular dysfunction, and neurological deficits in wild-type (WT) mice.
As such both endothelial derived vasodilators (e.g., NO) and vasoconstrictors (e.g., endothelin) are important in the development of macrovascular cerebral vasospasm and in microvascular dysfunction [ 81, 82].
We evaluated the coronary vasculature of gamma-sarcoglycan mutant mice and found microvascular filling defects consistent with arterial vasospasm.
Contributors to DCI including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction were measured 3 days later.
Outcome after aneurysmal subarachnoid hemorrhage (SAH) depends critically on delayed cerebral ischemia (DCI) – a process driven primarily by vascular events including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction.
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