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Microvascular leak Fig. 29 (abstract A893).
BAL Evans Blue demonstrated that microvascular leak was absent before deflation and was maximal by 10 min of deflation.
The endothelium plays a central role in the activation of coagulation, and activated/dysregulated endothelium contributes to microvascular leak and enhanced adhesion of leukocytes.
Which mediators are responsible for microvascular leak?
Increased endothelial barrier permeability, and the resultant microvascular leak, is known to become pathologic in the setting of sepsis.
Endotoxemia resulted in microvascular leak and reduction of tissue perfusion, which was ameliorated by MAT.Ang-1 post-treatment.
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In contrast, fibrin sealants have been reported to promote the closure of microvascular leaks caused by surgical trauma while also enabling faster healing and revascularization of wound tissue [ 39, 40].
The dual actions of angiotensin II (AngII) on microvascular fluid leak remain enigmatic.
Our hypothesis was that the AngII type 2 (AT2) receptor decreases microvascular fluid leak during inflammation.
This hypothesis is supported by the observation that lipopolysaccharide or platelet-activating factor-induced intravascular volume loss (microvascular fluid leak) was attenuated by LXA4, which may be partly mediated by the c-Jun N-terminal kinase signaling pathway [ 24].
'Treatable lesions' included discrete points of retinal hyperfluorescence or leakage (most of these are often microaneurysms), areas of diffuse leakage within the retina related to microaneurysms, intraretinal microvascular abnormalities, diffusely leaking retinal capillary bed and retinal avascular zones.
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