Chao, C. Y. & Cheing, G. L. Microvascular dysfunction in diabetic foot disease and ulceration.
This condition has been dubbed coronary microvascular dysfunction, or microvessel disease, and is sometimes referred to as Syndrome X.
Nearly 50% of subjects of coronary artery disease suffer from coronary microvascular dysfunction.
De Boer, M. P. et al. Microvascular dysfunction: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension.
Despite MAP and MFI were relatively preserved, the persistent microvascular dysfunction could explain metabolic disorders.
Additional fluid may increase interstitial edema and further comprise the microvascular dysfunction that characterizes severe sepsis.
Sepsis triggers inflammation and oxidative stress, and promotes microvascular dysfunction, which can lead to AKI.
Thus, microvascular dysfunction due to pericyte degeneration may initiate neurodegenerative changes[123].
Although other mechanisms are possible, the persistent metabolic alterations could be explained by the microvascular dysfunction.
This is especially relevant for critically ill patients, where microvascular dysfunction is frequently present.
A CFR value gives the information of microvascular dysfunction in addition to flow-limiting coronary artery stenosis [1, 11].
