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We have investigated the function of Crim1 in microvascular development in vivo.
The question arises as to what extent reduced microvascular development, in part engendered by inadequate organ perfusion, i.e., reduced regional macrovascular development, can physically restrict nutrient supply to developing organs.
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Therefore, abnormalities in placental microvascular development toughly compromise the supply of nutrients and hormones, leading ultimately to fetal growth restriction [ 85].
Pulmonary blood microvascular development is linked with alveolar development and both are impaired in CLD [ 4, 5].
Then in vivo, we assessed the effects of NaPaC on the A431 tumour growth, cell death and microvascular system development in xenografts implanted in nude mice.
We thus determined the time course of microvascular insulin resistance development in the setting of HFD feeding.
We aimed to characterize features of microvascular function during MetS development in a mouse model, particularly during the initial phase when confounding factors known to influence microvascular function are not completely established.
These challenges have been met with the development in microvascular tissue transfer techniques, with a variety of free flaps (fibular, ilium, radius, metatarsal, and scapula) available for mandibular reconstruction [8].
This clinical phenomenon is also apparent with Type 2 diabetics as demonstrated by the United Kingdom Prospective Diabetes Study UKPDSS) where a "sustained legacy" of microvascular complication development was evident in the conventional treatment group despite being under intensive treatment recommendations for the past ten years [ 6].
Microvascular disease is a major pathogenic factor for chronic kidney disease (CKD) in persons with diabetes, but the role of microvascular disease in the development of CKD in the general population is unclear.
We speculated that blood pressure variability may also have an influence on the development of microvascular complications in diabetes.
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