Sentence examples for microvascular density in from inspiring English sources

In a previous study [22] we showed that a liposomal formulation of CN limited tumor growth and significantly reduced microvascular density in a xenograft animal cancer model.

We demonstrated a reduction in angiogenesis in vivo as determined by decreased microvascular density in the histological sections of matrigel plugs containing S100A7-downregulated cells and high-concentration growth factor-reduced matrigel as compared to the S100A7-vector cellsol cells when injected into mice.

These findings, together with the lack of correlation noted between VEGFR-2 and the microvascular density in these tumors reinforce the idea that the role exerted by VEGF/VEGFR-2 in melanoma is primarily implicated in promoting melanoma cell growth and may be independent of the development of a tumor related capillary network [21], [22].

In conclusion, fractionated radiotherapy decreases microvascular density in experimental malignant glioma.

In addition, Smac/DIABLO expression correlated positively with microvascular density in these patients.

We found that doxorubicin causes a decline in microvascular density in a dose-dependent fashion.

A decrease in microvascular density occurred in parallel with a significant decrease in the relative frequency of galectin-3 positive cells present within the tumour microenvironment, as shown in Fig. 4D.

We observed a significant decrease in microvascular density (MVD) in response to low dose metronomic cyclophosphamide chemotherapy in both malignant melanoma (with higher proportion VEGFR2 positive blood vessels; 93%) and colorectal carcinoma (with lower proportion VEGFR2 positive blood vessels; 60%) xenografts.

Finally, examination of the explanted hearts showed a downward trend in infarct size and an upward trend in microvascular density (MVD) in the hESC-EC treated group, though these differences with controls were not statistically significant (Figure S6).

This suggestion is reinforced by the slight but significant decrease in microvascular density observed in WEB2170-treated animals.

We observed a significant difference in tumor microvascular density only in the B20-4.1.1/PTX treatment group compared to other groups (p < 0.05) (Fig. 4f).