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Therefore, PbA induced microvascular damage in both lungs and brain is LTβR signaling dependent.
This new discovery of microvascular damage in mice even at early disease stage may have implications for disease pathogenesis.
Possible causes of this erythropoietin hyporesponsiveness include systemic inflammation and microvascular damage in the bone marrow (15, 20).
20 For example, sRAGE was shown to protect blood vessels against AG E RAGE-mediatedmicrovascular damage in patients with T2DM.
The presence of diabetes complications, including proliferative retinopathy and nephropathy, could reflect microvascular damage in the ovary (7).
A decrease in BP dip has been previously associated with microvascular damage in patients with type 1 diabetes [ 12].
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One might not forget that the best way to reverse low COP and microvascular damages in sepsis remains early and adequate anti-infectious treatment.
Aldose reductase (ALR) is involved in diabetic microvascular damage via the polyol pathway.
The combination of hyperglycemia, insulin resistance, dyslipidemia, hypertension, and chronic inflammation injures the vascular endothelium, resulting in microvascular damage (alterations in capillary density and vascular permeability), macrovasculopathy, and CVD.
It could be explained by the theory that microvascular damage characterized in T2DM is also exhibited in the central nervous system.
Specifically, the loss of pulsatile flow damping by the proximal aorta may result in increased structural and functional microvascular damage, particularly in the heart, brain, retina, and kidney.
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