Along with inflammation, these alterations in the microstructure and tissue composition of cervical tissue in WAD patients are possible mechanisms which could lead to elevated [11C]D-deprenyl retention.
Many studies have shown that ultrasonic wave propagation in tissues is strongly dependent on histological features including cell structure, cell number density, tissue microstructure, and tissue heterogeneity [ 13- 24].
Correlation between the alteration of diffusion parameters and tissue microstructure is not yet entirely clear.
However, in all modeling studies reported so far numerous simplifications were made in terms of representing biophysical details of cellular function and its heterogeneity, gross anatomy and tissue microstructure, as well as the bidirectional coupling between electrophysiology (EP) and tissue distension.
However, the precise relationship between CTTA and tissue microstructure is less well defined.
These abnormalities include early amyloid accumulation [ 63- 65], regional hypometabolism [ 63], atrophy [ 66, 67], and alterations to functional connectivity [ 68] and tissue microstructure [ 66, 69].
Further details on the theoretical and signal analysis considerations and the relationship between spectral parameters and tissue microstructure can be found elsewhere [ 19, 21].
DW-MRI contrast provides different, and complementary, information to DCE-MRI, being sensitive to factors that affect this microscopic water motion, such as cell density, membrane integrity and tissue microstructure.
A group-level region-of-interest (ROI) analysis of the fMRI data was conducted to identify clusters reflecting a significant relationship between BOLD response for faces and scenes and tissue microstructure of the ILF and fornix, respectively.
DW-MRI is developed to probe the microscopic motion of water molecules, and the measured apparent diffusion coefficient (ADC) is sensitive to cell density, membrane integrity, and tissue microstructure [ 62].
We have identified an apple cultivar ('Scifresh') where the fruit softens slowly despite having high ethylene production, providing a system for investigating the cell wall and tissue microstructure without the confounding influence of ethylene.
