In conclusion, 12 months of treatment with BZA/CE in OVX rats effectively maintained BMD, bone microstructure, and bone quality; and the pairing of BZA with CE prevented CE-induced uterine stimulation.
Because Caribbean Hispanic women have higher genetic admixture of African ancestry, we hypothesized that they would have better bone microstructure and bone strength than Caucasian women.
Contrast and inverse difference moment have linear correlation with BMD in OP group; this suggested that the mechanism of trabecular bone connectivity to bone microstructure and bone quantity under different disease conditions can be very complex and require further study.
This is because OXA, TPM, and LTG may alter bone microstructure and bone turnover rate but maintain an adequate bone mass, leading to a normal statural growth rate in vivo and a normal proliferation of bone cells in vitro.
Among nutrients, protein deficiency has been shown to play an important role in the pathogenesis of osteoporosis and fragility fracture Animal studies have shown that an isocaloric low protein intake decreases bone formation [ 2, 3], leading to a negative bone balance and deterioration of bone mass, bone microstructure, and bone strength in both female and male adult rats [ 2, 4].
Importantly, precision for bone density, macro- and microstructure at the MH, MS and UUD radius regions we report in our imaging facility was comparable to previously reported values for distal radius and metacarpal head bone microstructure and bone mineral density measurement precision using HR pQCT [ 21, 53].
We examined the differences in aBMD, bone microstructure and estimated bone mechanical competence in two groups of American postmenopausal women: Caucasian and Hispanic of Caribbean origin.
Ito et al. [ 17] described the correlations between microstructure parameters and bone strength.
Specifically, the improvement of microstructure and subchondral bone remodeling following treatment with PAM would markedly contribute to the avoidance of progression of cartilage damage in our experimental model.
26 30 Taken together, these new insights into bone microstructure and other aspects of bone quality build upon prior DXA data to more comprehensively explain the epidemiology of fracture in the Chinese.
More prospective data relating microstructure, mechanical competence and bone remodeling to the prediction of fracture across races are needed.
