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This work is focused on the in-silico determination of the role of scaffold microstructural anisotropy in bone tissue regeneration.
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It is revealed that microstructural anisotropy exists in both the as-sprayed and annealed CS deposits.
Results for these uniaxial compression tests in the finite strain regime through ramp strain and ramp-relaxation loading histories applied over two orders of strain rate magnitude show that microstructural anisotropy is directly manifested in the bulk viscoelastic solid-like response.
Microstructure was carefully examined and microstructural anisotropy was confirmed.
The in-plane to out-of-plane anisotropy is expected from the microstructural anisotropy.
In this way localization has been linked to microstructural anisotropy developed during the first loading path.
We hypothesized that two fabrication parameters, 1) preservation (P) or removal (R) of a dense collagen layer present in SIS and 2) SIS in a final dehydrated (D) or hydrated (H) state, have an effect on scaffold void area, microstructural anisotropy (fiber alignment) and mechanical anisotropy (global mechanical compliance).
Two kinds of loading axes were chosen for the compression tests with respect to the microstructural anisotropy.
We investigate the microstructural anisotropy of the basalt fiber reinforced polypropylene composites and evaluate their mechanical properties, such as elastic modulus and ultimate tensile strength in order to understand the relationship between the local anisotropy and the mechanical strength of the composites.
The influence of microstructural anisotropy on shear response of high-purity titanium was studied using the compact forced-simple-shear specimen (CFSS) loaded under quasi-static loading conditions.
However, the main conclusion of the work is that initial scaffold microstructural anisotropy has important consequences since it determines the spatial distribution of the newly formed tissue.
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