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Electron microscopy of cardiac myocytes showed a lack of organized sarcomeres.
Electron microscopy of cardiac tissue sections revealed redistribution of cardiac mitochondria in MeCP2-TG hearts from interfibrillar and subsarcolemmal locations to the perinuclear region.
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The most detailed three-dimensional structure for a eukaryotic NaV is a low-resolution (19 Å) cryo-electron microscopy structure of a channel from the electric eel Electrophorus electricus, 5) and the only structures for calcium channels are even lower-resolution (25 and 23 Å, respectively) negatively stained electron microscopy structures of cardiac (L-type)(6) and muscle (T-type)(7) CaVs.
To determine whether the density and distribution of GFP+ cTMs changes with age, we conducted confocal microscopy on cardiac sections from Cx 3cr1 GFP/+ mice aged 4, 8 or 30 weeks (Fig. 3A).
An independent verification of the DIGE analysis was performed by immunoblotting and confocal microscopy of a select group of cardiac proteins.
We used CD31, Runx1, Kit and CD41 whole-mount immunofluorescence and confocal microscopy to examine the structure of cardiac blood islands in Nf1-deficient ventricles at E11.5.
To assess the ultrastructural integrity of cardiac tissue slices, both transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were used.
Octn2 was detected on the plasma membrane of cardiac muscle cells by immunoelectron microscopy.
Using high-resolution video microscopy and optical voltage mapping we have demonstrated depression of cardiac contractility indices and a significant increase in ventricular action potential duration at 48 hpf following loss of hadp1.
Using high resolution episcopic microscopy (HREM) and three-dimensional (3D) modelling, a range of cardiac defects, including AVSDs similar to those seen in humans with DS, were found in Tc1 mouse embryos (Dunlevy et al., 2010).
In addition, expression of selected proteins of interest were analysed with immunofluorescence microscopy in cardiac tissues after long-term thermal acclimation.
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