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By providing direct quantitative and qualitative microscopy evidence, the results of this study demonstrate for the first time that the passive delivery of an edge-activated liposomal formulation can effectively carry siRNA through the stratum corneum and deposit it at the lower epidermis/upper dermis.
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Immunofluorescence microscopy evidenced the peripheral cell localization of Sulfolobal DING protein, along the plasma membrane hedge.
The morphological analysis carried out by scanning electron microscopy and transmission electron microscopy evidenced the formation of a 3D nanostructure consisting of a copolymer-embedded TiO2nt.
Electron microscopy evidenced the presence of some unmyelinated axons in the interlobular spaces or septa, usually located adjacent to blood vessels and the exocrine epithelial ducts.
Raman spectrometry, X-ray diffraction and transmission electron microscopy evidenced the formation of homogenous configurations, with well-dispersed G-COOH layers within the PSF matrix.
However, the response surface ANOVA showed that sizes and piroxicam content were not affected by the granulation conditions and microscopy evidenced the presence of piroxicam crystals on granules surface.
Scanning and transmission electron microscopy evidenced the formation of a matrix typified by ZrB2-cores surrounded by (Zr,Mo B2-rims with dispersed Mo B2-rimsicles and SiO2 glass trapped at the triple junctions.
Recombinant Pseudomonas strains induced CaCO3 precipitation at a comparable rate as S. pasteurii and scanning electron microscopy evidenced the complex of CaCO3 crystals and EPS layers surrounding the cells.
For the first time confocal microscopy evidenced the nuclear localization of GAGs and proteoglycans [ 20– 20].
More recently, Wignes et al. demonstrated that congenital cataract in the αBR120G crystalline mutant mouse is associated with maintained expression of SQSTM1 and inhibition of autophagy, and Costello et al. provided extensive electron microscopy evidence of the presence of autophagic vesicles in the lens.
This has long been presumed based on transmission electron microscopy evidence of the lack of a fibrillar surface coat anterior to the moving junction (Aikawa et al., 1978) and as previously suggested by comparison of MSP183 with RON4 during invasion (Riglar et al., 2011).
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CEO of Professional Science Editing for Scientists @ prosciediting.com