Intranasally delivered CTG (6 µl) was detected by microscopic detection of CellTracker Green throughout the hippocampus and cerebellum 5 hours after administration (Figure 2).
For example, as early as 1920, Frost developed a method for rapidly detecting microbial growth by microscopic detection of nascent microcolonies [1].
To complement assays that assess HR by measuring its end points (10– 13), and as a rapid means of detecting proteins involved in HR-mediated repair, many researchers have used microscopic detection of RPA or other HR-associated proteins within punctate subnuclear foci at DNA damage sites to assess progression into and through the various stages of HR (14– 14).
Commonly used methods for diagnosing Onchocerca volvulus infections (microscopic detection of microfilariae in skin snips and nodule palpation) are insensitive.
(a) Microscopic detection of Bb in a cross-section of a leaf mid rip from a Bb-treated leaf at 200-fold magnification.
The diagnostic PCR assay developed in this study was shown to be more effective for detection of K. septempunctata from cultured olive flounder (10 out of 10 fish positive) than microscopic detection of spores in tissue homogenates (5 out of 10 fish positive).
Microscopic detection of twitching activity was deemed an indicator of the establishment of bacteria-cell interaction.
As early as 1959, Chance and Thorell reported microscopic detection of single autofluorescent yeast cells [13].
In experimental human malaria infection, complement activation was observed prior to microscopic detection of parasitemia [50].
All cases were confirmed by laboratory testing, either by isolation of the agent in culture or by microscopic detection of characteristic yeast forms in biopsy or aspirate specimens.
A more pronounced difference in prevalence based on one versus two days of sampling was only observed for microscopic detection of P. falciparum, where prevalence increased by 24%.
