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Its genetic basis has been recognized; but histopathologic changes, especially electron microscopic changes, have scarcely been described.
Macroscopic and microscopic changes have been observed in the meniscus along the degenerative process of the knee.
Therefore, mutational load analysis may provide additional information to aid in clinical diagnosis and management when such microscopic changes have yet to occur or are indefinite.
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The structural changes have been observed both on macroscopic and microscopic scale.
Further microscopic investigation of the slow isomerization process may lead to a better understanding of enzyme inhibition where large-amplitude conformational changes have not been identified.
Many cases will not show any clinically significant resorption but, microscopic changes are likely to have occurred on surfaces which are not visualised with routine radiographs.
However, a reliable method for detecting microscopic changes in early OA has not yet been established.
Stages 1 and 2 CKD must have associated urinary microscopic changes (either hematuria and/or proteinuria) in addition to an eGFR <110 mL·min−1 to fulfill the diagnostic criteria for stage 1 or 2 CKD.
The microscopic changes seen a week after laser treatment have been described in detail in previous communications (Möller et al, 1996, 1997, 1998).
"The change has been microscopic," said Tommy Jacquette, 61, a participant in the riots and a friend of Frye, who died in 1986 of pneumonia.
But they said the images confirmed for the first time that tobacco smoke can cause microscopic changes in the lung.
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