Small regions of DNA known as microsatellites are very prone to mutating, creating a kind of genetic fingerprint that's different from one family to another.
Microsatellites are very informative and are useful to assess genetic variability, analyze mating systems and in genetic mapping.
In spite of the known facts that repeat variation of microsatellite loci is critical for their maintenance in the genome and in some cases may have functional consequences, our understanding of motif imperfection in microsatellites is very limited.
These authors have observed that despite the low frequency of polymorphism found in A. hypogaea, these microsatellite loci were very informative and could provide a useful tool to identify and partition genetic variation in the cultivated peanut.
After sequencing the variants, evolutionary relationships among alleles can be inferred much more accurately than for microsatellites, which are very susceptible to homoplasy [ 2].
Among the trinucleotide repeats, we found AGC microsatellites to be very common, representing 37.1% of the total for the tri-nucleotide SSR as might be expected since this was one of the motifs used as a hybridization probe.
The 11 microsatellite markers used in this study were very informative and showed a high ability to detect polymorphism within analyzed genotypes.
Recent ICI clinical trials showed that ICIs were very effective for late stage microsatellite instability high (MSI+) patients4,5 and the FDA granted accelerated approval for using MSI- + as a biomarker for ICI treatments.
In contrast to the clear disparity in the total number of microsatellites in the V. volvacea and A. bisporus genomes, the proportion of the six microsatellite categories was very similar.
