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Here, we report that four of these microsatellites, spanning a 47 Kb interval containing the DXS225 locus, are in complete linkage disequilibrium, thus providing a hypervariable and highly informative haplotype block for inference about human evolution [8].
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In addition, these microsatellites span a relatively large section of the MHC compared to the 2 5 MHC loci typically sampled in past research [27], [28], [30].
The resulting linkage map of 107 microsatellites spans a total sex-average length of 886.6 cM, with 10 LGs.
For example, on Tgu1A the microsatellites span a predicted 24.4 Mbp and the linkage distance is 15.8 cM, whereas a similar region covering 21.7 Mbp is only 0.6 cM on the SNP map.
We hypothesized that mutations in EDNRB, KIT, or PDGFRA control at least one type of white spotting pattern in the domestic cat, and we performed a linkage analysis of ventral (bicolour) white spotting using a panel of five microsatellites spanning these three genes.
In the present study, a genetic map of 5703 SNPs and 7 microsatellites spanning 1514 cM was constructed.
A total of 5,459 Israeli Holstein cows, daughters of 11 sires, were genotyped for 29 microsatellites spanning chromosome 7 and analyzed by the daughter design for 9 economic traits: milk, fat, and protein yield, fat and protein percentage, somatic cell score, female fertility, herd life, and milk persistency.
Conserved microsatellites spanning more than one element were positioned in the element with the longest overlap.
The scan included genotyping 29 microsatellites spanning the chromosome in 11 sires families.
For instance, MICdb [ 9] provides information on microsatellites spanning coding and non-coding regions, their frequency, size and repeat sequence.
Similarly, microsatellites spanning desired genomic regions can be selected and used for further saturation of existing molecular maps.
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