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Furthermore, irrespective of the microsatellites, some of the amplified regions represent valuable marker regions for a number of applications [ 39].
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According to the results of the GALK1 microsatellite, some of them share the same genotype as the cases.
Two introns contained microsatellites in some of the species.
First, differential intrinsic slippage rates among species, generating more abundant and larger microsatellites in some of them.
In the case of microsatellites, some simulation replicates demonstrated dramatic departures from the mean value of D for microsatellites.
In addition to TATA elements, we identified several other motifs, primarily representing microsatellite elements, some of them overrepresented in particular regions of core promoters.
Furthermore, the variability of local recombination rates among maps correlated with the abundance of microsatellites and with some of the sequence motifs that correlated with the average recombination rate.
Microsatellites show some populations of pure ancestry (inferred via STRUCTURE), that tend to cluster geographically, but also many admixed populations and individuals.
Because of the higher number of mitotic cell divisions in male than in female germ lines, it is plausible to expect that evolution of microsatellites, to some extent, is male-driven [ 14, 15].
High frequencies of microsatellites in some regions outside hotspots are also not conclusive evidence against their functional involvement, since the control of hotspot location has been shown to be complex and multi-levelled, with local and distal sequences, transcription factor binding and chromatin structure alterations all implicated (reviewed in [ 46, 48, 67]).
In H. sapiens, about 11% of all microsatellites are part of a compound microsatellite (Table 1).
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