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Strong phylogeographic association of mtDNA (two clades), compared to microsatellites, has also been previously documented in e.g. blue marlin [ 64].
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The sequence properties of microsatellites have also been studied in a variety of organisms.
Microsatellites have also been used for the detection of drug-resistant variants of parasites [ 49].
Microsatellites have also been associated with increased genomic diversity by promoting sequence duplications, gene conversion, crossovers, and generating local recombination hotspots [ 45, 48- 52, 53] 53].
Microsatellites have also been shown to increase the frequency of mutations in the surrounding nucleotide sequences (Amos 2010c, 2010b; Varela and Amos 2010).
Microsatellites have also proven useful for defining several other avian subspecies (Chan and Arcese 2002; Funk et al. 2007b; Draheim and Haig, unpublished manuscript).
Molecular breeding aided by microsatellite marking has also been reported [ 27, 28].
An adjacent microsatellite, D6S1590, has also shown evidence of linkage and association with RA in the same families [ 9].
Comparative genotypic analysis of microsatellite markers has also been used in an attempt to reveal the clonal origins of epithelial and mesenchymal components of tumors.
Furthermore, hMLH1 methylation-associated microsatellite instability has also been strongly associated with tumors that express the CpG Island Methylator Phenotype (CIMP) [ 36].
High-frequency microsatellite instability phenotype has also been reported in sporadic CRC (10 15%), but somatic mutations in MMR genes are rare in these cases (Peltomaki et al, 1993; Kuismanen et al, 2000; Kamory et al, 2003).
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