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Microorganisms have evolved a number of macromolecular secretion machineries to translocate proteins and nucleoprotein complexes from the bacterial cytosol to the host cell.
Microorganisms have evolved a multitude of mechanisms for coping with stressful conditions, including both general and stress-specific response mechanisms [ 11].
Intracellular microorganisms have evolved a variety of siderochromes, which are special ligands that can dissolve insoluble Fe3+ and facilitate its transport into the cell in order to acquire Fe from Tf and other Fe-proteins in the host.
Microorganisms have evolved a variety of mechanisms for coping with arsenic toxicity, including minimizing the amount of arsenic that enters the cell (e.g. through increased specificity of phosphate uptake, [ 2]), arsenite oxidation through the activity of arsenite oxidase [ 3, 4], or peroxidation reactions with membrane lipids [ 5, 6].
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However, most microorganisms have evolved to utilize a preferred sugar in the presence of other sugars, enabling them to grow quickly under nutrient limited conditions [ 32].
Due to the indiscriminate use of antibiotics, microorganisms have evolved into resistant strains and a numbers of antibiotics have lost their effectiveness against those microorganisms in recent years [9].
But, in turn, some microorganisms have evolved many different approaches to circumvent this barrier, a direct consequence of natural co-evolution.
A number of pathogenic microorganisms have evolved original strategies to pass through the apical epithelial barrier and penetrate into the intestinal epithelium.
Although 2C4NP is released into the environment for a relatively short period, several microorganisms have evolved their ability to degrade this xenobiotic (Ghosh et al. 2010; Arora and Jain 2011; Pandey et al. 2011; Arora and Jain 2012; Tiwari et al. 2017).
Arsenic is an environmental pollutant and some microorganisms have evolved mechanisms of resistance to this cytotoxic agent.
Microorganisms have evolved to occupy almost every conceivable ecological niche and energy-generating mechanism.
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