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Examples for shear stress sensitive microorganisms, for which no specific cultivation systems exist, are many anaerobic bacteria and fungi, such as basidiomycetes.
Such a resource would greatly facilitate the exchange of reference spectra between research groups and thus allow identifying microorganisms for which no reference spectra have been generated in a particular lab [21].
These investigations place B. mallei among the limited number of microorganisms for which NO congeners are microbicidal.
Indeed, 25% of our etiologic diagnoses correspond to microorganisms for which the diagnosis is usually based on serologic testing.
In cases of PJI sustained by highly virulent microorganisms for which there is limited medical therapy, the arthrodesis or resection arthroplasty may be a viable option as the second stage surgery [ 20].
The approach we have developed here is general and can be used to engineer production of a variety of products in different microorganisms, for which constraint-based models exist.
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Overall, the results of this study indicate that combination of systems biology approaches and biological systems diversity is a useful tool to gain novel insights into the physiology of biotechnologically important microorganisms, from which new strategies for rational optimization of strains and cultivation conditions could be derived.
The distinction may be subtler in amoebae, for which microorganisms are both a source of food and potential pathogens.
Although CCR is considered a common regulation mechanism for microorganisms, there are several microbes for which simultaneous utilization of mixed carbon sources has been reported.
On the other hand, it should be search for microorganisms, which are able to decompose biodegradable plastics at temperatures as low as possible.
Casadevall and Pirofski [ 3] proposed a new definition of pathogenicity and pathogenicity determinants for microorganisms which encompassed the state of a host's immunological defenses.
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