Sentence examples for microglial clearance of from inspiring English sources

Overall, our findings uncover a novel mechanism that SIRT1 protects against Aβ deposits by facilitating microglial clearance of Aβ other than preventing neuronal production of Aβ.

Considering the critical role of TFEB in lysosomal biogenesis, we intended to explore whether TFEB would increase microglial clearance of Aβ and unveil the mechanisms underlying the upstream regulation of TFEB in lysosomal biogenesis in microglia.

Here, we further show that the p44/42 and p38 pathways confer a significant reduction in microglial Aβ phagocytosis and that pre-treatment with selective inhibitors of either p44/42 or p38 significantly upregulates microglial clearance of Aβ peptide (Fig. 2C).

Of these, immunotherapy protocols aimed to up-regulate the microglial clearance of cerebral A β, whereas an alternative strategy used anti-inflammatory agents to reduce microglial neurotoxicity.

The authors implicated CD33 as a regulator of microglial clearance of Aβ and proposed it as a target for the treatment and prevention of AD.

We had observed interestingly that while microglial depletion and microglial phagocytosis inhibition exerted rescue effects by decreasing microglial clearance of living rods, these measures also resulted in a significantly decreased density of TUNEL+ photoreceptors.

These studies suggest that one action of APOE is regulation of brain innate immunity, where the APOE4 allele may cause a proinflammatory microglial state and impaired microglial cell clearance of toxic molecules.

Our observations above indicate that microglial depletion and microglial phagocytosis inhibition, in addition to diminishing microglial phagocytic clearance of stressed but living rods, decreased the density of TUNEL+ photoreceptors.

Ageing is associated with senescence of microglia and impaired microglial clearance functions.

Such defective microglial clearance functions have recently been supported by long-term in vivo imaging of amyloid plaques.

Inefficient microglial clearance has been reported to be prevalent in several neurodegenerative diseases and to increase with aging [ 22].