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Immune suppression in the tumour microenvironment remains a major limitation to successful immunotherapy of cancer.
Despite the recognised contribution of the stroma to breast cancer development and progression, the effective targeting of the tumor microenvironment remains a challenge to be addressed.
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Despite the significant progress made during the last decade, designing materials to control cellular microenvironment remains an important goal.
However, mechanisms to exert specific control over cellular microenvironments remains a significant challenge.
However, the role of peritumoral DR in a necroinflammatory microenvironment remains to be elucidated in HCC.
Whether this reflects a different cellular phenotype, a different amount of MSC in the synovium-derived population compared with BM-MSC adherent cell populations or the impact of a different microenvironment remains to be determined.
Although the importance of the host tissue microenvironment in cancer progression and metastasis has been established, the spatiotemporal process establishing a cancer metastasis-prone tissue microenvironment remains unknown.
However, whether DL-101+ cells represent a distinct subset specific to in vitro culture microenvironment remains to be further investigated.
Although incorporation into the tumor microenvironment is apparent, the role of recruited MSC in the tumor microenvironment remains unclear.
The relationship between lysophosphatidic acid (LPA) and the tumor microenvironment remains poorly understood.
While all the studies above suggest cell integration by means of oligodendroglial and neuronal differentiation as potential mechanisms for recovery of function after SCI, the possibility of additional mechanisms whereby engrafted cell populations contribute to endogenous repair within the host microenvironment remains unexplored.
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CEO of Professional Science Editing for Scientists @ prosciediting.com