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The immunosuppressive tumor microenvironment poses a significant barrier to the effectiveness of cancer immunotherapies.
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Sorting out the effects of VEGF inhibition on the tumour microenvironment poses challenges because multiple cell types within the tumour microenvironment express VEGFRs.
Although reduced expression of ISGs in the liver of chronic HBV patients mirrors that in PBMCs, 31 the intrahepatic microenvironment poses additional limitations to the effector arm of antiviral immunity.
The microenvironment in the bone metastases poses a considerable challenge for the infiltrating CAR T cells (see Fig. 2).
In many instances, the body's natural barriers, and those constructed in the malignant microenvironment, still pose an insurmountable obstacle for the accumulation of efficacious drug levels at the tumor.
Which poses a puzzle.
This poses a puzzle.
This poses a serious problem.
Bahrain poses a different problem.
Their indifference poses a problem.
Medicare poses a larger quandary.
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