Sentence examples for microenvironment is thought from inspiring English sources

The thymic microenvironment is thought to play a critical role in T-lymphocyte development, providing signals both via cell surface molecules such as adhesion molecules and soluble molecules.

Furthermore, a 'niche' microenvironment is thought to be important in the regulation of stem cell quiescence and differentiation.

The presence of Foxp3+ cells in the tumor microenvironment is thought to inhibit host-protective antitumor responses and especially CTL activity [ 6].

In stem cell niche, the stromal microenvironment is thought to provide a rich milieu of molecular signals and growth factors that mediate HSCs self-renewal and differentiation.

The mechanisms by which dormant tumour cells are at one point triggered to start proliferating are yet unaccounted for, however, the microenvironment is thought to play a regulatory role.

In addition to different DCs that are present in the spleen and inguinal LN, the tissue microenvironment is thought to have a major impact on the nature of immune responses induced at difference tissue sites.

Chemokines found within the tumour microenvironment are thought to play at least five roles in the development of tumours and metastatic disease; (a) control leukocyte infiltrate, (b) modify tumour immune response, (c) regulate angiogenesis, (d) operate as growth and survival factors, and (e) direct the movement of tumour cells themselves [27].

Neuroinflammation and a perturbed microenvironment are thought to be important in the dysregulation of neurogenesis seen after irradiation (IR).

Because changes in the stromal tumour microenvironment are thought to contribute to invasion and spread of tumours (De Wever and Mareel, 2003), we compared the expression levels of colXI α1 in cancer-associated fibroblasts and normal oral fibroblasts derived from cancer-free patients.

Notably, some hematological tumors arise from defects in bone marrow stroma that lead to an abnormal microenvironment, which is thought to contribute to tumorigenesis and drive tumor progression, providing an example of how ECM changes might promote non-epithelial malignancies (Dror and Freedman, 1999; Michigami et al., 2000).

RA synovial fibroblasts (RASFs) create an abnormal stromal microenvironment that is thought to be crucial for the persistence of inflammation, not only because of its architecture, but also by secreting pro-inflammatory cytokines or by producing growth factors that stimulate neovascularization.