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Many chemokines that induce migration of macrophages have been identified during inflammatory responses; however, further precise analysis of macrophage migration in the tumor microenvironment is required.
Coordinated signaling between tumor cells and nonmalignant inflammatory cells in the tumor microenvironment is required for the development of tumors.
Moreover, no variations in BMP2 or BMP7 transcripts were observed in BM cells upon in vitro exposure to imatinib (not shown), suggesting that the whole BM microenvironment is required for imatinib to exert its complete effect.
Coordinated signaling between tumor cells and nonmalignant cells in the tumor microenvironment is required for the progression of tumors, and signaling pathways that regulate the crosstalk between colon tumor cells and stroma, such as NF-κB and STAT3, have emerged as important targets for chemopreventive and chemotherapeutic agents [3], [4].
More generally a specific microenvironment is required to let biominerals crystallize [ 8].
It is therefore clear that the crosstalk between tumor cells and their surrounding microenvironment is required for HCC development.
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Recently, Kwon et al found that Jagged-1 signaling from BM microenvironment was required for EPC development [24].
Immunotherapeutic methods for attracting DC into, and activating DC within, the tumour microenvironment are required to improve the antitumour immune response.
Interactions between tumour cells and host organ microenvironments are required for tumour invasion and metastasis.
Analyzing the patterns of tumor development, the classic hypothesis of «seed and soil» looks very actual [38], which postulated that an appropriate microenvironment (soil) is required for optimal growth of tumor cells (CSCs).
Laminin also plays a major role in the remodelling of the melanoma microenvironment, and is required for melanoma vasculogenic mimicry and activation of integrin signalling [ 27].
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