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In the hybrid single-cell-based models, the microenvironment is represented by continuous concentrations of oxygen, nutrients, matrix, and drugs.
In MM, microenvironment is represented by the cellular component of a normal bone marrow together with extracellular matrix proteins, adhesion molecules, cytokines, and growth factors produced by both stromal cells and PC themselves.
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The inflammatory microenvironment was represented in our current study by TNFα and IL-1β.
The first is the way in which sites, or local protein microenvironments, are represented; the second part concerns model building and supervised machine learning methods; and the third involves site scoring and model evaluation.
A defined site (a set of residues) is represented by describing the physiochemical and structural environments surrounded around each residue, referred as FEATURE microenvironment.
It seems that the interaction between plants and their root-zone microenvironment is not equally balanced, as the condition of the plants is highly influenced by the conditions in their root zone microenvironment, while these microenvironment conditions (as they are represented by the measurable variables) are not influenced in the same degree by the conditions of the plants.
In addition, because tumor samples used here were not microdissected, tumor gene expression data are represented together with the stroma, which may reveal signaling between the microenvironment and tumor cells.
Additionally, the metastases were reported to be influenced by liver microenvironment that can be represented by inflammation/immune response-related signatures of differentially expressed genes [ 14].
Modulating tumor microenvironment is a clinically relevant therapeutic strategy, and as a natural regulator of this microenvironment, SPARC represents a highly promising therapeutic modality.
Further, the tumor microenvironment is both heterogeneous and complex.
The bone microenvironment is also hypoxic [19].
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