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The cellular microenvironment is recognized to play a key role in stabilizing cell differentiation states and phenotypes in culture.
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Cells of the tumor microenvironment are recognized as important determinants of the tumor biology.
Inflammatory factors are important constituents of the tumor microenvironment, and inflammation is recognized as a key factor in cancer (Kim et al. 2009; Mantovani et al. 2008).
It is recognized that this microenvironment presents specific biomechanical signals that strongly influence stem cell behavior.
The "systematic targeted drug delivery" or "whole-process targeting" is recognized as an effective brain tumor targeted drug delivery strategy which considers all the possible targets including barriers, microenvironment and cancer cells.
Apart from these genetic factors, desmoplasia and tumor microenvironment have been recognized as key contributors to PDAC chemoresistance.
Although the expression of PECAM-1 (CD31) on vascular and haematopoietic cells within the bone marrow microenvironment has been recognized for some time, its physiological role within this niche remains unexplored.
Recently, the tumor microenvironment has been recognized as the place of crosstalk between different cell types and cellular signaling [ 10, 22].
Bone marrow stromal cells became quiescent, organized themselves forming a meshwork, deposited extracellular matrix, and formed specialized microenvironments that were recognized by hematopoietic CD34+ cells.
Indeed, interactions with the tumor microenvironment or stroma are recognized as one of important "hallmarks of cancer".
The tumor microenvironment is increasingly recognized as an important player in tumor promotion and progression.
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