Sentence examples for microenvironment is needed from inspiring English sources

More understanding of the bacterial location in the lung throughout disease progression and the bacterial in vivo microenvironment is needed to elucidate the host-pathogen interaction further.

In order to faithfully and precisely investigate the cancer cells' response to anticancer drugs, a stable, well-defined, and biologically relevant cellular microenvironment is needed.

The results of these studies indicate that the tumor cells are not activated through autocrine stimulation by CXCL12, but rather that a paracrine loop involving CXCR4-CXCL12 sinnaling in the tumor microenvironment is needed for EGF-induced in vivo invasion in Neu-YB tumors.

Finally, since neutrophils, the airway epithelium, and microorganisms all contribute to CF lung disease, integrative approaches combining signals from all components of this pathological microenvironment are needed to yield better understanding of the mechanisms at play.

In vivo studies of the molecular components of complex immunological processes within the tissue microenvironment are needed to test these models in man.

Such a delayed immune reaction may explain the increase in apoptotic CTCs observed; however, additional studies including analyses of immune infiltrating cells and the immune milieu of the tumor microenvironment are needed to establish this as a mechanism of action.

Model animals that closely and reliably mimic the human tumor microenvironment are needed to evaluate the antitumor activities and develop effective therapeutic regimens involving liposomal anti-cancer drugs and drugs whose effects, such as antiangiogenesis, require interaction with the blood vessels, as the usefulness of such drugs depends on the tumor microenvironment [ 9].

These results indicate that tumor microenvironment imbalance is needed for miR-34a′s expression and this basal expression may be reduced if these stimuli are either withdrawn (T3) or increased (E2).

In addition, targeting of CK to these cellular microenvironments localizes CK activity where it is needed, optimizing enzyme distribution [ 7].

However, more experimentation is needed to better recapitulate tumor microenvironment and to account for the influence of the lymphatic system on tumor growth and metastasis.

However, further research is needed to determine whether JPJD positively impacts the liver microenvironment during liver cancer by regulating the levels of OATP1B2 or ABCC2.