Sentence examples for microenvironment is mediated from inspiring English sources

Detailed recent studies designed to delineate the mechanisms of tumor cell IDO-induced immunosuppression showed that the effect of IDO in the tumor microenvironment is mediated through increased differentiation of Treg cells at the tumor site, systemic expansion of myeloid cells and marked recruitment of myeloid-derived suppressor cells (MDSCs) into the tumor microenvironment [179].

One component of the interaction between the tumor and the microenvironment is mediated by the immune system via "immunoediting" [3].

Maybe in cancer development, Treg migration into the tumor microenvironment is mediated by the CCL5-CCR5 axis.

Adaptive behavior of cancer cells in the highly heterogeneous microenvironment is mediated by induction of changes in gene expression thereby reprogramming signaling pathways.

Spranger et al, 2013 demonstrated in a murine mechanistic experiments that the induction of PD-L1 in melanoma microenvironment is mediated by IFN-y produced by the T cells that are antigen experienced and therefore express PD-1.

Treg cells migration into the tumor microenvironment is mediated by the CCL5/CCR5 axis in pancreatic adenocarcinoma, and blockade of this pathway may represent a novel immunomodulatory strategy for the treatment of cancer.

In addition, the phenotype of infiltrating immune cells in the tumor microenvironment was mediated by cytokines, chemokines and other inflammatory mediators [ 16].

In many cancers, the influences of the microenvironment are mediated in part by paracrine signaling between epithelial cancer cells and the surrounding stromal cells [ 41, 42].

The primary regulator of VEGF secretion is the hypoxic microenvironment, which is mediated by the transcription factor hypoxia-inducible factor 1- α (HIF-1 α).

The product of PI4KB catalysis is phosphatidylinositol 4-phosphate (PI4P) and coronavirus entry into the host is mediated by the PI4P lipid microenvironment [ 38].

The antitumor activity is mediated by both i) the inhibition of the immunosuppressive tumor microenvironment which increases intratumoral lymphocyte infiltration, and ii) enhanced functionality of the infiltrating lymphocytes.