Changes in cell adhesion and migration in the tumor microenvironment are key in the initiation and progression of metastasis.
The adhesive and migratory abilities of tumor cells and the tumor microenvironment are key components involved in cancer metastasis [2], [3].
These aspects are particularly important when studying tumours, since macrophages that are present in the tumour microenvironment are key actors in both angiogenesis and tumour immune escape.
Nevertheless, how T-lymphocytes are recruited into the tumor site and whether they can remodel the tumor microenvironment are key questions that remain unclear.
As discussed in the Salk Institute news release that was issued last year, Ron and his colleagues knew that the ability of the pancreatic tumor to communicate with nearby cells -- called the tumor microenvironment -- is key to its growth.
Regulating gene expression to microenvironment-specific conditions is key to the ability of bacterial pathogens to infect and cause disease.
From traditional and emerging angiogenic cytokines and their receptors to novel immune checkpoint inhibitors, regulation of the tumor microenvironment is potentially key in countering tumor progression.
The interplay between hematopoietic stem and progenitor cells (HSPC) and their local microenvironment is a key mechanism for the organization of hematopoiesis.
However, cytokine microenvironment is a key point also in targeted therapeutic vaccinations, such as allergen-specific immunotherapy, where the interference with an already-existing but inappropriate immunity is required.
Our results reveal another important fact that tumor inflammatory microenvironment is a key player in activating MSCs to induce chemoresistance of HCC cells.
