Sentence examples for microenvironment is essential from inspiring English sources

A 3D microenvironment is essential for the cell adhesion and proliferation necessary to achieve the desired regeneration of damaged tissues or organs.

The cross-talk between tumor epithelium and surrounding stromal/immune microenvironment is essential to sustain tumor growth and progression and provides new opportunities for the development of targeted treatments focused on disrupting the tumor ecology.

However, since cell ECM interactions vary considerably between two-dimensional (2-D) and three-dimensional (3-D) models, understanding their influence over normal and pathological cell responses in 3-D systems that better mimic the in vivo microenvironment is essential to translate such insights efficiently into medical therapies.

Hence, the use of in vivo orthotopic models, faithfully reproducing the tumour microenvironment, is essential for the analysis of metastasis-related mechanisms [15] [18].

These results indicate that the microenvironment is essential for VEGFA-induced tumour growth.

An increasing body of evidence shows that the tumour microenvironment is essential in driving neoplastic progression.

Moreover, MSCs themselves were reported to have strong contractile ability in mono-culture (Sumanasinghe et al., 2009; Espagnolle et al., 2014) and similar results were also obtained in this study (Fig. S1), implying that specific microenvironment was essential to stimulate the therapeutic potential of MSCs.

Signals from the microenvironment are essential to direct normal tissue development and, in the adult organism, to maintain tissue-specific functions (Nelson and Bissell, 2006).

Signals from the bone microenvironment are essential to determine DTC fate, and BM is an ideal "soil" able to promote growth of the primary "seed" [ 9].

In vivo, signals from the microenvironment are essential for normal development and organ homoeostasis, and abnormalities in these signals contribute to various pathologies including tumorigenesis (Ingber, 2003; Nelson and Bissell, 2006).

The tumor microenvironment plays a major role in cancer development and progression, and interactions between cancer cells and the microenvironment are essential both for the growth of the primary tumor and for the migration of metastatic cells to distant organs and their survival there.